Nat.Prod.Res 2005;19(6):567-571. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. However, there is concern that herbs like ashwagandha may have interactions that have . Is It Safe To Take Keflex (Cephalexin) With Birth Control? Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Acta Oncol. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. Ashwagandha can also interact with some medications and affect how they work. Tumori 8-31-1994;80(4):306-308. O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. Effect of a medicinal plant (Passiflora incarnataL) on sleep. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. View abstract. 2020;40(4):825-829. However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. The combination could decrease the effectiveness of these medications. 2012;7(9):e44419. Headache. These side effects are usually experienced on higher doses. TSH Suppression. 2019;98(37):e17186. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. 8-16-1995;95(1-2):189-193. Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Therapeutic Research Faculty 2020. J Clin Med 2021;10(16):3644. Diarrhea. Nutrients. 2019;11(9):e5797. A systematic review and meta-analysis of randomized controlled trials. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Adv Exp Med Biol. Indian J Exp Biol 2000;38:607-9. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. PLoS One 2021;16(9):e0257843. J Med Food 2022. View abstract. Memorial Sloan-Kettering Cancer Center: Ashwagandha, NYU Langone Medical Center: Ashwagandha Interactions You Should Know About, NYU Langone Medical Center: Benzodiazepines, "Therapeutic Drug Monitoring"; Herbal Supplements and Therapeutic Drug Monitoring; A. Dasgupta; April 2008, University of Maryland Medical Center: Anaphylaxis. Ultimately, the supplements and foods you can . However, you should not stop taking any prescribed medication. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. Be sure to talk with your doctor about this and all drugs you are taking, especially digoxin. Its effect on arterial blood pressure in anaesthetized dogs. Sud Khyati S, Thaker B. Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. It is just a general precaution that ashwagandha may decrease blood sugar. Can You Take Lyrica And Flexeril Together? 8-19-2005;334(1):276-287. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Deshpande A, Irani N, Balkrishnan R, Benny IR. Yakugaku Zasshi 2008;128(8):1159-1167. View abstract. . Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. Medicine (Baltimore). Upadhaya L and et al. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. While supplement and drug-induced serotonin syndrome poses a major risk for people taking SSRIs, other antidepressants can require stricter dietary changes. Ashwagandha, also known as 'Indian Ginseng' is an evergreen shrub indigenous to India, the Middle East, and some parts of Africa. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Integr Cancer Ther. Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. View abstract. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. View abstract. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Underactive Thyroid. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Evid Based Complement Alternat Med. Evid Based Complement Alternat Med. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Liver Int. View abstract. ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. Phytother.Res 2010;24(1):129-135. Although, it's important to note that long-term studies have not been performed on ashwagandha. This is one of the more common food-drug reactions. Hence, be cautious if taking these medications and want to take Ashwagandha also. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. View abstract. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions Chauhan S, Srivastava MK, Pathak AK. View abstract. Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. Thank you, {{form.email}}, for signing up. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Yes: Ashwagandha is a wonderful tonic that reduces inflammation, balances hormones and supports immune function. Phytomedicine 2000;7(6):463-469. Ashwagandha might increase how much thyroid hormone the body produces. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Ashwagandha may be able to help with insomnia. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. It was concluded that participants from all five studies found improvements in their anxiety. I have it on my medical HelloPharmacist Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? IV. J Diet Suppl. Arch Pathol Lab Med 2007;131:1298-303. View abstract. Do not use this product if you have stomach problems or ulcers. Take extra care if you are at a high risk for infection. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. Staff. 1998;20(1):191-198. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. Liver Int. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. . J Ayurveda Integr Med. Use birth control you can trust while taking this product. View abstract. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Take extra care if you are taking iron supplements. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. What about black My Dr. put me on 500mg of cephalexin 3 times a day and 150mg of fluconazole. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Hidese S, Ogawa S, Ota M, et al. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. Upton R, ed. She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. Ashwagandha has also been used to increase performance among athletes and improve male infertility. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cureus 2022;14(10):e30433. Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. What Happens If I Take Too Much Ashwagandha? Immunopharmacol.Immunotoxicol. This dosing has also been associated with improvements in memory. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Do not use this product if you are pregnant or plan to become pregnant soon. Available for Android and iOS devices. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Dasgupta A, Tso G, Wells A. View abstract. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Drug Metabol.Drug Interact. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Ashwagandha has no known moderate interactions with any drugs. 2020;34(5):1041-1059. There is concern that ashwagandha interacts with anesthesia commonly used in surgery. View abstract. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). A total of 0 drugs are known to interact with ashwaganda. 2004;42(12):2015-2020. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. It is mandatory to get consent from the doctor before taking it. Researchers of the study believed that these results were due to the ability of ashwagandha to moderate the body's stress response. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Talk with a healthcare provider about the right ashwagandha dosage for your needs. View abstract. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. 2011;68(1):3-8. 2012;10(1):48-49. Medically reviewed by Drugs.com. Dosage: How Much Ashwagandha Should I Take? Indian J Exp Biol. Cureus 2022;14(10):e30787. 1965;9(1):9-15. Sleep Med. Can I Take Lexapro & Vitamin Supplements? Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Do note that ashwagandha itself does not . 2019;11(12):e6466. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Certain supplements may contain ingredients that are dangerous when mixed with specific medications, even if they are safe on their own. All rights reserved. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. Taking ashwagandha along with these medications might decrease the effects of these medications. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. View abstract. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Ashwagandha has mild interactions with at least 29 different drugs. View abstract. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. Remenapp A, Coyle K, Orange T, et al. The news available in this regard in . 2012;10(1):48-9. hydrochlorothiazide, spironolactone, chlorthalidone). Often, herbs and supplements come with a risk of side effects. It's important to keep all supplements out of reach of small children and pets who may accidentally ingest more than they should. Expert Rev Clin Pharmacol. Mandlik Ingawale DS, Namdeo AG. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. J Ethnopharmacol. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). View abstract. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Ghosal S, Lal J, Srivastava R, and et al. View abstract. Phytother Res. Aerobic capacity and recovery were assessed for all participants throughout the study. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. There are a variety of vitamins and minerals that are essential for good health. J Diet Suppl. Staff, Cotellic With Turmeric And Black Pepper Interaction. For more information, read the "What else do I need to know?" section below. J Ethnopharmacol 1999;64:91-3. As with many other herbal supplements, little research is available on possible interactions. Some people should avoid using ashwagandha due to safety concerns. Be sure to tell your doctor if you are breastfeeding. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Ashwagandha May Interact With Certain Drugs. Take extra care if you are taking drugs to help with your thyroid. Am J Drug Alcohol Abuse 2009;35(1):1-11. They also are not very good drugs, because they have multiple potentially . These include drugs like thyroid desiccated, levothyroxine, or liotrix. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. Read our. No, that's not true all the time. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. Panda S, Kar A. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. Long-term safety studies on ashwagandha are lacking. 2020;10(11):e01760. View abstract. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. 2019;11(12):e6466. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Monitor your blood pressure closely. View abstract. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Never start, stop or otherwise change your therapy before speaking with your provider. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. View abstract. In the study, no adverse events were reported by participants who took the herb. In comparison, a small human trial published in 2022 showed additional proof that ashwagandha may be helpful for people living with anxiety. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. All rights reserved. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. Indian J Exp Biol. Herb-drug interactions. 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. You can also use ashwagandha as an herbal tea. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. One clinical trial evaluated how ashwagandha root extract affects memory and overall cognitive function. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. 2020;72:28-36. You can mix other nonessential amino acids and antidepressants without any issues. Mental health statistics show between 3 and 5 percent of adults live with a depressive disorder globally, according to a January 2014 study in Depression and Anxiety. Monitor your blood sugar closely. Hypothyroidism, After Thyroid Removal. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Some of these interactions can be life-threatening. 2020;12(2):e7083. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Ashwagandha may interact with certain drugs by enhancing or negating their actions.
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