The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. Patients diagnosed with COVID-19 of all ages and racial groups will be included. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. See this image and copyright information in PMC. Buy The research results revealed that Lianhua Qingwen Capsules effectively improved the total effective rate of COVID-19 treatment, as it significantly ameliorated the symptoms of cough, fever and fatigue of patients, improved the disappearance rate of main symptoms, and shortened the duration of main symptoms on the basis of routine treatment. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. The composition of Lianhua Qingwen granules is consistent with the pathogenesis of the disease. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Please try again soon. 6.Patients with fever over 38.5 , should go to the hospital. The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. A: Chest radiograph of normal people; B: Chest radiograph of a. The conclusion of this review will provide evidence to judge whether Lianhua Qingwen combined with Conventional antiviral Western Medicine is an effective and safe intervention for COVID-19. Select all eligible studies published before May 8, 2020. doi: 10.1097/MD.0000000000021404. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. Treatment of Sars-Cov-2: how far have we reached? In 2010, Diagnosis and Treatment Scheme for Wind-warm Lung-heat Disease (Non-severe Community Acquired Pneumonia) (2010), issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine Ephedra was banned from the Olympics and other sport events, even in the US military. It has important clinical significance for alleviating the severity of COVID-19 and shortening the course of disease. A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020). In China, lianhua qingwen is recommended for treating thepneumonia. In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission A park employee (R), seen wearing goggles and face mask, walks in a park in Beijing on March 14, 2020. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. Biotechnology communication 2003;14:3902. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Consult with doctors or pharmacists before administration if other medicines are received during this time. Here are links to the publications that published the results of the clinical trial :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229744/https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtmlIngredients & ContradicationsPlease refer to the pictures for more informationUSAGE FOR RESPIRATORY DISEASES SUCH AS FLUS AND COLDSProphylaxis: If you know you are going out, take LHQW the day before, the day of the outing and the day after the outing. Meanwhile, China also provides technical solutions through long-distance video exchanges to share treatment experience with Japan, South Korea, Italy, the United States, Iran, Singapore, and so on. Keyword Highlighting [15]. [14]. Why is it important to subscribe? It contains 13 herbs that are anti-viral and anti-inflammatory. The data extraction form will include the following items: Two reviewers/authors (ZXL and ZQ) will independently evaluate the quality of the included trials through assessing the risk of bias using the following tools, when appropriate: The following aspects of included trials will be assessed: sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, incomplete outcome data, and selective outcome reporting. It is approved by HSA asan over-the-counter traditional Chinese medicine to treat influenza and colds. | 2023 ACTSmarket, capsules x 3 times a day ( after breakfast, lunch and dinner. 15. This product should be administered strictly in accordance with dosage and administration, and is not for long-term use. An official website of the United States government. Even The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. China's top respiratory expert,the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. Effectiveness and Safety of Lianhua Qingwen Capsules for COVID-19: A Propensity-Score Matched Cohort Study. The general public is reminded that LHQW is only a traditional Chinese medicine and not a therapeutic drug for Covid-19. BecauseLHQWhas multiple ingredients, other possible interactions with any of its ingredients could also occur. Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic. cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. PLoS One. A: Before treatment; B: After treatment. To consume within 2 weeks after opening. [25]. [1]. Patients with body temperature higher than 38.5 should see the doctor. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. To systematically determine the effect of Lianhua Qingwen Capsules on the early antiviral and anti-inflammatory action against COVID-19 (Coronavirus 2019) and its applicational value in the treatment of COVID-19. 2018;Beijing: Science and Technology Literature Press, 13271329. GRADE: an emerging con- sensus on rating quality of evidence and strength of recommendations[J]. Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. a non-profit social enterprise that collaborates with other SE producers to build capacity in marketing, sales and operations. 1. J Integr Med. Upgrade to Rappler+ for exclusive content and unlimited access. In accordance with the usage and dosage,the product should not be long term used. 8600 Rockville Pike This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For oral use after meals,4 capsules one time and thrice daily. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. Lianhua Qingwen capsule (granule) is an Innovative Patent Chinese medicine for the treatment of influenza, which was developed by the green channel of the new drug approval during the SARS period in 2003 based on the pathology of collateral of traditional Chinese medicine. The assessment will be adjudicated into 4 levels: high, moderate, low, or very low. V03AX - Other therapeutic products ; Other products with therapeutic properties. Records from databases and other resources will be uploaded to a database created by EndNote9.7 software. 13. Chinese Journal of nosocomial infection 2015;25:7279. FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine [23]. We plan to carry out the following subgroup analyses if possible: the study area is different, the average course of disease is different, and the length of treatment is different. [34]. Hongying Mo, Zifeng Yang, Jinping Zheng, et al. Product PackingEach box contains 24 capsules in blister packing. Holshue ML, DeBolt C, Lindquist S, et al. Federal government websites often end in .gov or .mil. Wu Yiling. Novel coronavirus pneumonia treatment plan issued by the national health and Health Committee, State Administration of traditional Chinese medicine (trial version sixth) [EB/OL]. In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission [36]. Medicine (Baltimore). Lianhua Qingwen was developed by Shijiazhuang Yiling Pharmaceutical in 2003 as a treatment for severe acute respiratory syndrome (SARS) following the outbreak of the disease in 2002 and was listed by the National Health Commission of China in 2004 as a treatment for influenza and other respiratory disease. The Chinese embassy in the Philippines announced this on Wednesday, August 12, hailing it as an important progress in the entry of TCM products into the Philippine market.. Traditional Chinese medicine, such as Lianhua Qingwen, has achieved some curative effect in many countries, but its effect is not clear. Race to find. Data synthesis reports the intervention effect of the original study by integrating the cohort study. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. 2023. Lianhua Qingwen (LHQW) Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. Add your comment to start the conversation. Search for Similar Articles [18]. XLZ conceived of the study, and perform this review. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. While it has been included in the standard treatment for coronavirus patients in China, it faces hurdles in the West where scientists raise questions over the evidence and effectiveness of traditional medicine. Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. Journal of Central South University for Nationalities: Natural Science Edition 2012;31:204. For more information, please refer to our Privacy Policy. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. Dichotomous outcomes will be presented as risk ratio and 95% confidence intervals (CIs), and continuous outcomes will be presented as mean difference/standard mean difference and 95% CIs. It is compatible with Rhodiola to clear lung and remove blood stasis. Third, the capsule can shorten fever & coughting time. Fish catch in Guimaras decreased by 29.6 percent from 7,844.53 metric tons in 2021 to 5,517 metric tons in 2022, as reported by the Chinese supplement Lianhua Qingwen: What you need to know, LOOK FOR BACKUP POWER: MORE Power assures 100% supply after weekend, Marcos prods NGCP to address energy woes in Western Visayas, Remains of two persons found dumped in concrete pipe, Guimaras fish yield down by 29.67% in 2022, DOE: Power reserves may run low in May, June, Globe secures ~P40.5B from its P91-B tower sale and leaseback, USTR keeps PH out of watchlist for 10 years, cites best, Iloilo taekwondo team hailed as overall champions in 2023 WVRAA meet, Gilas Pilipinas frontcourt woes continue as Aguilar & Erram ruled out, Kaya FC-Iloilo demolishes Mendiola FC in PFL clash, NBA Playoffs: Currys record-breaking 50-point Game 7 leads Warriors past Kings, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first, Expert advice on identifying and treating allergic asthma, WHO and IAPAC sign a memorandum of understanding focused on ending, WHO launches new initiative to improve pandemic preparedness, 90% of countries report disruptions to essential health services since COVID-19 pandemic, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first time in Q1, WHO and IAPAC sign a memorandum of understanding focused on ending epidemics in cities. Yuewen Ding, Lijuan Zeng, Runfeng Li, et al. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. National Library of Medicine The flow diagram of this systematic review is shown in Figure 1. < 5 years: not recommended because it may be difficult for young children to swallow capsules. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. The findings of the trial showed strong indications of LHQW in helping patients recover faster and in the prevention of severe covid disease, when compared to the control group using only standard treatment. Disclaimer. In WANFANG, novel coronavirus pneumonia, 2019-nCOV, COVID-19, and SARS-COV-2 were first searched for the keywords, then searched for the theme word Lianhua Qingwen and Lianhua Qingke. The 2 search were merged with the relationship. Novel coronavirus pneumonia is being set up by CNKI for the new research project. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. Therefore, the completeness of the evidence is not yet available. Lianhua Qingwen formula is based on the theory of collateral disease, to reveal the law of transmission of respiratory infectious diseases caused by virus. If I2 test 50%, a random-effects model will be used for data analysis instead. If 2 eligible RCTs are identified, meta-analysis will be performed with Review Manager 5.3. In 2009, Diagnosis and Treatment Scheme for Patients Infected with Type A H1N1 Influenza (2009), issued by the State Administration of traditional Chinese medicine Pregnancy & lactation. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). You may search for similar articles that contain these same keywords or you may The authors have no conflicts of interest to disclose. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsuleare as follows: First, after taking the capsule, patients' symptoms improve quickly, recovery rate up to 91.5%, conversion to severe cases down to 2.1%. Since all the data included are published, the systematic review does not need ethical approval. Methods: This product should not be used in treatment of wind-cold. As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtml, Lianhua Qingwen Jiangnan (LHQW) for Flu and Colds. Below dosage is a guide only. The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. Before Clinically, Lianhua Qingwen Capsule can be used in the treatment of cold, flu-induced bronchitis, pneumonia, COPD, interstitial pneumonia and other lung inflammation. All data generated or analyzed during this study are included in this published article [and its supplementary information files]. Chunyuan Liu, Xiaoqiang Li, Shaoqian Cai. Progress in pharmacology and clinical research of Lianhuaqingwen capsule [J]. Individuals w/ cold deficiencies in spleen & stomach or w/ qi. 2020 Sep 11;15(9):e0238828. The abstracts of all studies will be independently screened by the review authors (XLZand QL). All the prescriptions are used to clear the toxic heat in the lung, clear the lung qi, and cut off the disease. Select all eligible studies published before May 8, 2020. The 3 drugs and 3 parties in China have been effective in many countries around the world, and once again reveal the special advantages of the Chinese herbal medicine overall adjustment and multi target therapy, which suggests the application of Lianhua Qingwen granule. In 2011, Diagnosis and Treatment Guide for Influenza (2011), issued by the Ministry of Health Wu C, Chen X, Cai Y, et al. 2.Its not appropriate to take nourishing chinese medicine wihte taking medicine. In addition, it can also interact with other compounds and herbs. Wenwen Cui, Xin Jin, Yanfen Zhang, et al. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe. We may also contact the original authors to provide additional relevant information, if necessary. Copyright 2023 MIMS Pte Ltd. All rights reserved. Children should be administered under adults supervision. Bioinform Biol Insights. The site is secure. However, this systematic review will have some limitations. It has a history of abuse by athletes due to its ability to increase energy and alertness and help weight loss. [12]. Because the novel coronavirus pneumonia has not yet been completely subsided, more large-sample clinical studies are still ongoing. Statistical heterogeneity will be assessed with the I2 statistic. Used in treatment of epidemic influenza and lung heat, symptom as fever or high fever, aversion to cold, muscular soreness, rhinostegnosis and nasal discharge, cough, headache, dry and sore throat, flushing tongue, or greasy fur of tongue. In this study, 100 participants were Go and see the doctor if the symptom is not alleviated 3 days after administration. Some error has occurred while processing your request. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. All randomized controlled trials (RCTs), Retrospective cohort study (RCSs), Comparison before and after the study (BAs) of Lianhua Qingwen combined with Conventional antiviral Western Medicine for COVID-19 will be included. FREE SHIPPING within SG when you buy 4 boxes or more. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. [Description]Capsules, containing tan to brown granule and powder; odour, slightly aromatic; taste, slightly bitter. STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. Study on the anti Staphylococcus aureus biofilm formation of Lianhuaqingwen capsule [J]. Objective: Bookshelf Statistical analysis was conducted by Revman 5.3 software. LHQW won the 2nd prize of the National Scientific and Technological Progress Award in 2011 for the treatment of influenza. Higgins JPT, Thompson SG, Deeks JJ, et al. Before the successful development of targeted vaccine, >4 million patients with covid-19 and asymptomatic infection around the world may also benefit from traditional Chinese medicine such as Lianhua Qingwen. Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Dont take this medicine if the description has changed. WebChronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations. Writing review & editing: Xiaolin Zhang. 2020;99:30(e21404). [3]. The manuscript was drafted by XLZ and MJL. There is no effective antiviral drug for COVID-19. Hai Guo, Jin Yang, Jiening Gong, et al. Writing original draft: Xiaolin Zhang, Di Cao. In PubMed, MEDLINE, and EMBASE, search with Lianhua Qingwen and COVID-19 as subject words. Please try after some time. 2023 Feb 17;2023:6028554. doi: 10.1155/2023/6028554. Avoid prolonged use. Xiaoyan Liu. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. A trial of lopinavirritonavir in adults hospitalized with severe. government site. Hermetically sealed,keep in cool and dry places. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. Ding Y, Zeng L, Li R, et al. The capsule is hugely popular and controversial as it traces its roots to a prescription that date back to classic medical texts written during the Han dynasty (206BC220AD), according to a report from the South China Morning Post.
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